• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Pulsed vs continuous light accelerated corneal collagen crosslinking: in vivo qualitative investigation by confocal microscopy and corneal OCT
【2h】

Pulsed vs continuous light accelerated corneal collagen crosslinking: in vivo qualitative investigation by confocal microscopy and corneal OCT

机译：脉冲与连续光加速角膜胶原交联：通过共聚焦显微镜和角膜OCT进行体内定性研究

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: To assess qualitative corneal changes and penetration of pulsed and continuous light accelerated crosslinking by in vivo confocal microscopy and corneal OCT.\udMETHODS: A total of 20 patients affected from progressive keratoconus were enrolled in the study. Ten eyes of 10 patients underwent an epithelium-off pulsed-light accelerated corneal collagen crosslinking (PL-ACXL) by the KXL UV-A source (Avedro Inc.) with 8 min (1 s on/1 s off) of UV-A exposure at 30 mW/cm(2) and energy dose of 7.2 J/cm(2); 10 eyes of 10 patients underwent an epithelium-off continuous-light accelerated corneal collagen crosslinking (CL-ACXL) at 30 mW/cm(2) for 4 min. Riboflavin 0.1% dextran-free plus hydroxyl-propyl-methylcellulose solution (VibeX Rapid, Avedro Inc.) was used for a 10-min corneal soaking. Treated eyes were examined by in vivo scanning laser confocal analysis and spectral anterior segment OCT at 1, 3, and 6 months.\udRESULTS: Epithelial stratification and nerves regeneration improved in time, being complete at month 6 in both groups without endothelial damage. Keratocyte apoptosis in PL-ACXL was estimated at a mean depth of ∼200 μm, whereas an uneven demarcation line was detectable by confocal microscopy at a mean depth of 160 μm in CL-ACXL.\udCONCLUSION: In vivo confocal microscopy and corneal OCT allowed a precise qualitative analysis of the cornea after epithelium-off PL-ACXL and CL-ACXL treatments. Apoptotic effect was higher in pulsed than in continuous light treatments, exceeding 200 μm in corneal stroma. According to different morphological data, the clinical efficacy of ACXL needs to be determined in a long-term follow-up and large cohort of patients
机译：目的：通过体内共聚焦显微镜和角膜OCT评估定性角膜变化以及脉冲和连续光加速交联的穿透性。\ udMethods：共有20名受进行性圆锥角膜影响的患者入选。 10位患者的10只眼通过KXL UV-A光源（Avedro Inc.）进行了8分钟（1秒开/ 1秒关）的上皮关闭脉冲光加速角膜胶原交联（PL-ACXL）。暴露于30WmW / cm（2）和能量剂量为7.2 J / cm（2）; 10例患者的10眼以30 WmW / cm（2）的速度进行了4分钟的上皮关闭连续光加速角膜胶原交联（CL-ACXL）。使用0.1％不含葡聚糖的核黄素加羟丙基甲基纤维素溶液（VibeX Rapid，Avedro Inc.）浸泡10分钟的角膜。通过活体扫描激光共聚焦分析和光谱前节OCT在1、3和6个月检查治疗的眼睛。\结果：上皮分层和神经再生及时改善，两组均在第6个月完成，而没有内皮损伤。结论：PL-ACXL的角膜细胞凋亡的平均深度约为200μm，CL-ACXL的共聚焦显微镜可检测到不均匀的分界线。\ ud结论：体内共聚焦显微镜和角膜OCT允许上皮脱PL-ACXL和CL-ACXL处理后角膜的精确定性分析。脉冲治疗的细胞凋亡作用高于连续光治疗，在角膜基质中超过200μm。根据不同的形态学数据，ACXL的临床疗效需要在长期随访和大量患者中确定

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号